Susceptibility to thiosemicarbazide (an antagonist of vitamin B6), and phylogenetic and ontogenetic development of brain.

Susceptibility to TSC1 (an antagonist of vitamin B6) was compared in seven animal species together with the protective effect of B61 on the induction of convulsions. Susceptibility to TSC occurred generally with the phylogenetic development of the brain of vertebrates as well as invertebrates. Abnormal behavior analogous to running fit in rat or mouse, which was thought to be a characteristic and activated form of locomotion, was also induced in every animal except the silkworm. In this experiment B6 was capable of arresting the induction of con vulsions and abnormal behavior in guinea pig and gold-fish.